Since SEGA of Europe enabled mods for its SEGA Mega Drive / Genesis Hub / Collection on Steam for PC the community has gone wild with these. While some mods might raise some flags on weirdness, others double the fun, like the Streets of Rage 2: Puyo Wars by Candra Software’s Workshop (originally done by Lorenzo The Comic), which enables your favorite characters from the Puyo Puyo 16-Bit series onto Streets of Rage 2 Beat ’em up mechanics, the result is amazing.
Dude, it even has a boss punching fight with Satan! Get it here on Steam Workshop.